Immunohistochemical localization and quantitative expression of somatostatin receptors in normal human spleen and thymus: Implications for the in vivo visualization during somatostatin receptor scintigraphy.
Identifieur interne : 000D04 ( Main/Exploration ); précédent : 000D03; suivant : 000D05Immunohistochemical localization and quantitative expression of somatostatin receptors in normal human spleen and thymus: Implications for the in vivo visualization during somatostatin receptor scintigraphy.
Auteurs : RBID : pubmed:21765239English descriptors
- KwdEn :
- Adolescent, Adult, Child, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Pancreatic Neoplasms (metabolism), Pancreatic Neoplasms (pathology), Pancreatic Neoplasms (radionuclide imaging), Pentetic Acid (analogs & derivatives), Pentetic Acid (pharmacokinetics), RNA, Messenger (genetics), Receptors, Somatostatin (genetics), Receptors, Somatostatin (metabolism), Reverse Transcriptase Polymerase Chain Reaction, Spleen (metabolism), Spleen (pathology), Spleen (radionuclide imaging), Thymus Gland (metabolism), Thymus Gland (pathology), Thymus Gland (radionuclide imaging), Tissue Distribution, Young Adult.
- MESH :
- chemical , analogs & derivatives : Pentetic Acid.
- chemical , genetics : RNA, Messenger, Receptors, Somatostatin.
- metabolism : Pancreatic Neoplasms, Receptors, Somatostatin, Spleen, Thymus Gland.
- pathology : Pancreatic Neoplasms, Spleen, Thymus Gland.
- chemical , pharmacokinetics : Pentetic Acid.
- radionuclide imaging : Pancreatic Neoplasms, Spleen, Thymus Gland.
- Adolescent, Adult, Child, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Tissue Distribution, Young Adult.
Abstract
[111In-DTPA-D-Phe1]-octreotide scintigraphy allows the visualization of SRIF receptor (SSR)-expressing tumors, including thymic tumors, and normal tissues. While the spleen is clearly visualized, the thymus is not depicted, although both contain SSR.
DOI: 10.3275/7871
PubMed: 21765239
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunohistochemical localization and quantitative expression of somatostatin receptors in normal human spleen and thymus: Implications for the in vivo visualization during somatostatin receptor scintigraphy.</title><author><name sortKey="Ferone, D" uniqKey="Ferone D">D Ferone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 6-16132-Genoa, Italy. ferone@unige.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 6-16132-Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Pivonello, R" uniqKey="Pivonello R">R Pivonello</name></author><author><name sortKey="Kwekkeboom, D J" uniqKey="Kwekkeboom D">D J Kwekkeboom</name></author><author><name sortKey="Gatto, F" uniqKey="Gatto F">F Gatto</name></author><author><name sortKey="Ameri, P" uniqKey="Ameri P">P Ameri</name></author><author><name sortKey="Colao, A" uniqKey="Colao A">A Colao</name></author><author><name sortKey="De Krijger, R R" uniqKey="De Krijger R">R R de Krijger</name></author><author><name sortKey="Minuto, F" uniqKey="Minuto F">F Minuto</name></author><author><name sortKey="Lamberts, S W J" uniqKey="Lamberts S">S W J Lamberts</name></author><author><name sortKey="Van Hagen, P M" uniqKey="Van Hagen P">P M van Hagen</name></author><author><name sortKey="Hofland, L J" uniqKey="Hofland L">L J Hofland</name></author></titleStmt><publicationStmt><date when="2012">2012</date><idno type="doi">10.3275/7871</idno><idno type="RBID">pubmed:21765239</idno><idno type="pmid">21765239</idno><idno type="wicri:Area/Main/Corpus">001269</idno><idno type="wicri:Area/Main/Curation">001269</idno><idno type="wicri:Area/Main/Exploration">000D04</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Male</term><term>Middle Aged</term><term>Pancreatic Neoplasms (metabolism)</term><term>Pancreatic Neoplasms (pathology)</term><term>Pancreatic Neoplasms (radionuclide imaging)</term><term>Pentetic Acid (analogs & derivatives)</term><term>Pentetic Acid (pharmacokinetics)</term><term>RNA, Messenger (genetics)</term><term>Receptors, Somatostatin (genetics)</term><term>Receptors, Somatostatin (metabolism)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Spleen (metabolism)</term><term>Spleen (pathology)</term><term>Spleen (radionuclide imaging)</term><term>Thymus Gland (metabolism)</term><term>Thymus Gland (pathology)</term><term>Thymus Gland (radionuclide imaging)</term><term>Tissue Distribution</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Pentetic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term><term>Receptors, Somatostatin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Pancreatic Neoplasms</term><term>Receptors, Somatostatin</term><term>Spleen</term><term>Thymus Gland</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pancreatic Neoplasms</term><term>Spleen</term><term>Thymus Gland</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Pentetic Acid</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Pancreatic Neoplasms</term><term>Spleen</term><term>Thymus Gland</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Male</term><term>Middle Aged</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Tissue Distribution</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">[111In-DTPA-D-Phe1]-octreotide scintigraphy allows the visualization of SRIF receptor (SSR)-expressing tumors, including thymic tumors, and normal tissues. While the spleen is clearly visualized, the thymus is not depicted, although both contain SSR.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21765239</PMID><DateCreated><Year>2012</Year><Month>07</Month><Day>03</Day></DateCreated><DateCompleted><Year>2012</Year><Month>12</Month><Day>07</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1720-8386</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>5</Issue><PubDate><Year>2012</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of endocrinological investigation</Title><ISOAbbreviation>J. Endocrinol. Invest.</ISOAbbreviation></Journal><ArticleTitle>Immunohistochemical localization and quantitative expression of somatostatin receptors in normal human spleen and thymus: Implications for the in vivo visualization during somatostatin receptor scintigraphy.</ArticleTitle><Pagination><MedlinePgn>528-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3275/7871</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">[111In-DTPA-D-Phe1]-octreotide scintigraphy allows the visualization of SRIF receptor (SSR)-expressing tumors, including thymic tumors, and normal tissues. While the spleen is clearly visualized, the thymus is not depicted, although both contain SSR.</AbstractText><AbstractText Label="AIM" NlmCategory="OBJECTIVE">We evaluated whether the heterogeneity, the type, and the amount of SSR might explain this contrasting finding.</AbstractText><AbstractText Label="MATERIALS, METHODS, AND RESULTS" NlmCategory="RESULTS">By ligand-binding the number of [125I-Tyr11]-SRIF- 14 binding sites resulted comparable between the two tissues, whereas the number of [125I-Tyr3]-octreotide sites was significantly higher in the spleen (p<0.001). Quantitative RTPCR showed a significantly higher expression of sst2A mRNA in the spleen, whereas a significantly higher expression of SRIF and sst3 in the thymus. The highest density of sst2A in the spleen is in line with the in vivo uptake of [111In-DTPA-D-Phe1]- octreotide, which is considered a sst2-preferring ligand. The specificity is confirmed by the evidence that in vivo [111In-DTPA- D-Phe1]-octreotide uptake can be abolished during chronic administration of "cold" octreotide. Immunohistochemistry confirmed a preferential expression of sst2A on microenvironmental cells and of sst3 on lymphoid cells.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The heterogeneity of SSR expression and the higher SRIF content explain the lack of thymus visualization during scintigraphy, whereas thymic tumors, which do not express SRIF, are visualized. Apart from the affinity of the radioligand, also the efficacy of the internalization is crucial for the in vivo uptake, and both heterogeneity and SRIF content affect this process. These observations might have an important impact when interpretating in vivo visualization of SSR-positive lesions, and when treatment with novel SRIF analogs is considered.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ferone</LastName><ForeName>D</ForeName><Initials>D</Initials><Affiliation>Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 6-16132-Genoa, Italy. ferone@unige.it</Affiliation></Author><Author ValidYN="Y"><LastName>Pivonello</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Kwekkeboom</LastName><ForeName>D J</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Gatto</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Ameri</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Colao</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>de Krijger</LastName><ForeName>R R</ForeName><Initials>RR</Initials></Author><Author ValidYN="Y"><LastName>Minuto</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Lamberts</LastName><ForeName>S W J</ForeName><Initials>SW</Initials></Author><Author ValidYN="Y"><LastName>van Hagen</LastName><ForeName>P M</ForeName><Initials>PM</Initials></Author><Author ValidYN="Y"><LastName>Hofland</LastName><ForeName>L J</ForeName><Initials>LJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>07</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>J Endocrinol Invest</MedlineTA><NlmUniqueID>7806594</NlmUniqueID><ISSNLinking>0391-4097</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>(111)indium-DTPA-D-phe octreoide</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Receptors, Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>somatostatin receptor sst2A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>somatostatin receptor type 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>7A314HQM0I</RegistryNumber><NameOfSubstance>Pentetic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Immunoenzyme Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pancreatic Neoplasms</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pentetic Acid</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Receptors, Somatostatin</DescriptorName><QualifierName MajorTopicYN="N">genetics</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Spleen</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Thymus Gland</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>7</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>12</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">7871</ArticleId><ArticleId IdType="doi">10.3275/7871</ArticleId><ArticleId IdType="pubmed">21765239</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D04 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D04 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:21765239
|texte= Immunohistochemical localization and quantitative expression of somatostatin receptors in normal human spleen and thymus: Implications for the in vivo visualization during somatostatin receptor scintigraphy.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21765239" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |